Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics
Substrate binding to the cytochrome P450 OleP is coupled to a large open-to-closed transition that remodels the active site, minimizing its exposure to the external solvent.When the aglycone substrate binds, a small empty cavity is here formed between the I and G helices, the BC loop, and the substrate itself, where solvent molecules accumulate med